Obesity is one of the major public health concerns worldwide, associated with multiple metabolic diseases, cardiovascular issues, and other comorbidities. However, beyond lifestyle habits and the environment, genetics plays a fundamental role in its predisposition and development. Thanks to the genetic studies of N·GENE, health professionals have an innovative tool to design personalized and effective strategies for the treatment of obesity.

1. Genetics as a key piece in obesity

Obesity is not just the result of a caloric imbalance between intake and energy expenditure; behind this condition lies a complex interaction of genetic and metabolic factors. One of the most relevant genes in this context is FTO, which directly influences fat accumulation and appetite control.

Additionally, other genes such as MC4R, LEP, and POMC are also involved in regulating hunger, energy storage, and insulin resistance, making the approach to obesity even more complex.

2. The N·GENE approach to obesity treatment

The genetic tests from N·GENE allow for a detailed exploration of how genetics affects each patient. With a genotyping analysis of over 700,000 markers, using advanced Illumina technology, specific areas related to obesity and metabolism are studied.

Main areas analyzed in the context of obesity:

• Appetite and satiety control: Identification of genetic variants that influence eating habits.

• Responses to specific diets: Analysis of how the patient responds to a specific distribution of macronutrients, such as fats and carbohydrates.

• Metabolic risks: Evaluation of genetic predisposition to problems such as insulin resistance, type 2 diabetes, or metabolic syndrome.

• Hormonal regulation: Genes associated with the metabolism of key hormones like leptin and adiponectin, which influence weight control.

3. Creating a personalized plan based on results

With the information obtained from genetic studies, the health professional can develop a treatment plan tailored to the specific needs of the patient:

• Customized nutritional plan: Diets are designed according to how the patient's body responds genetically to certain nutrients. For example, it can be determined whether a low-carbohydrate diet or a high-protein diet is more effective. 

• Optimized physical exercise: According to the genetic markers related to strength, endurance, and predisposition to injuries, the type and intensity of recommended physical activity are adjusted.

• Specific supplementation and metabolic control: Identification of potential deficiencies in vitamins, minerals, and other nutrients that impact metabolic health to guide personalized supplementation.

4. N·GENE as an advantage in managing obesity

Genetic analysis allows for understanding and delving into the underlying causes of obesity, not just treating its consequences. This approach significantly increases the chances of success, as the patient knows that the treatment is designed exclusively for them, improving their commitment and adherence to the intervention, and thus the results.

Obesity does not have a one-size-fits-all solution. However, integrating genetics as a tool for personalization and prevention, as offered by N·GENE, represents a revolutionary change in managing this condition. Thus, health professionals can better understand the genetic basis of their patients to guide them towards a healthier and more sustainable lifestyle. If you would like more information on how to implement this innovative approach in your practice, feel free to contact us.