Coronary artery disease: variants in genes such as APOE, LPL, and LDLR can influence cholesterol and triglyceride levels, increasing the predisposition to this condition characterized by the buildup of plaques in the arteries that supply blood to the heart. 

The genetic predisposition to atrial fibrillation may involve variants in genes such as PITX2, ZFHX3, and KCNE1. These genes regulate cardiac electrical conduction, heart rhythm stability, and the function of ion channels, contributing to heart rhythm disturbances.

Blood pressure regulation is influenced by genes such as AGT and ACE, where certain variants may predispose individuals to increased sodium retention and altered vascular response, increasing the risk of hypertension.

The predisposition to stroke or cerebrovascular accident may be influenced by genetic variants in genes related to blood coagulation, vascular function, and blood pressure. Genes such as MTHFR, APOE, and ACE have been associated with an increased risk due to their role in regulating cerebral blood flow, clot formation, and the inflammatory response.

Polymorphisms in 9p21, a genetic region associated with vascular inflammation, have been linked to an increased risk of myocardial infarction, especially in people with a family history.

The predisposition to thrombosis may be influenced by genetic variants in genes such as F5, F2, and MTHFR. These genes are involved in blood coagulation. For example, mutations in the F5 gene, which encodes factor V, can lead to a form resistant to inactivation by activated protein C, increasing the risk of blood clot formation.