The genotype HLA-DQ2 and/or HLA-DQ8 is associated with a genetic predisposition to celiac disease, while its absence significantly reduces the likelihood of developing this condition. The identification of these genetic markers allows for the assessment of risk and improves the customization of dietary strategies, facilitating a more accurate diagnosis.

The genotype in variants of the gene AOC1 (DAO) may influence the ability to degrade histamine, which can increase the predisposition to intolerance to this biogenic amine. The variants that reduce the activity of the enzyme diamine oxidase (DAO) may favor the accumulation of histamine and trigger adverse symptoms.

The CC genotype at the SNP C/T_13910 indicates a high genetic predisposition to lactose intolerance, while the C/T or T/T genotypes indicate lactase persistence and thus a lower predisposition to this intolerance. Knowing this information allows for a personalization of guidelines and dietary treatments in professional consultation.

The variants in the SI gene, which encodes the enzyme sucrase-isomaltase, can affect the digestion of sucrose, predisposing individuals to intolerance to this disaccharide. Alterations in enzymatic activity can lead to digestive symptoms when consuming foods with sucrose. Identifying these variants allows for the personalization of diet and improvement of quality of life through tailored nutritional recommendations.